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After a registration is approved, a GIIN can be affected if the registration is edited, but it cannot be outright cancelled or removed solely due to an edit. Specifically, if the country of tax residence in question 3 of the registration is changed, this will affect the last three characters of the GIIN. These changes will not occur immediately but will take effect when the registration is reprocessed. Therefore, while the GIIN itself is not cancelled or removed, it can be modified based on certain edits to the registration.
Sources:
Rev. Proc. 2014-39
Publication 5118 (07/2021)
Notice 2013-43
